GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7551345 | 1 | rs4949377 | chr1:31758467 | ZCCHC17 | chr1:31769842-31837780:+ | -0.3 | -5.6 | 3.65E-8 | Schizophrenia |
| THCA | cis | rs7551345 | 1 | rs4949391 | chr1:31833706 | ZCCHC17 | chr1:31769842-31837780:+ | 0.31 | 6.19 | 1.27E-9 | Schizophrenia |
| THCA | cis | rs2444240 | 1 | rs494965 | chr11:120053650 | TRIM29 | chr11:119981995-120008863:- | -0.15 | -3.78 | 0.000174 | Corneal curvature |
| THCA | cis | rs7552404 | 1 | rs4949674 | chr1:76213715 | ACADM | chr1:76190043-76229353:+ | 0.13 | 3.68 | 0.000262 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7552404 | 1 | rs4949674 | chr1:76213715 | MSH4 | chr1:76262630-76378923:+ | 0.25 | 4.13 | 4.3E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7552404 | 1 | rs4949872 | chr1:76131392 | MSH4 | chr1:76262630-76378923:+ | 0.26 | 4.37 | 1.51E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7552404 | 1 | rs4949874 | chr1:76161889 | ACADM | chr1:76190043-76229353:+ | 0.12 | 3.38 | 0.000783 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7552404 | 1 | rs4949874 | chr1:76161889 | MSH4 | chr1:76262630-76378923:+ | 0.24 | 4.12 | 4.42E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7552404 | 1 | rs4949875 | chr1:76173080 | MSH4 | chr1:76262630-76378923:+ | 0.25 | 4.2 | 3.16E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7552404 | 1 | rs4949876 | chr1:76173377 | ACADM | chr1:76190043-76229353:+ | 0.12 | 3.36 | 0.000836 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7552404 | 1 | rs4949876 | chr1:76173377 | MSH4 | chr1:76262630-76378923:+ | 0.24 | 4.1 | 4.94E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7552404 | 1 | rs4949879 | chr1:76237143 | ACADM | chr1:76190043-76229353:+ | 0.13 | 3.59 | 0.000361 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs7552404 | 1 | rs4949879 | chr1:76237143 | MSH4 | chr1:76262630-76378923:+ | 0.25 | 4.29 | 2.2E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs4950322 | 1 | rs4950322 | chr1:146854836 | FMO5 | chr1:146655885-146697230:- | -0.26 | -4.09 | 5.08E-5 | Protein quantitative trait loci |
| THCA | cis | rs4950322 | 1 | rs4950429 | chr1:146871957 | FMO5 | chr1:146655885-146697230:- | 0.24 | 3.87 | 0.000125 | Protein quantitative trait loci |